In the movie, Frank (Bill Murray  Stripes, Caddyshack) is a mega-slob who really doesn't care how he lives, but there lies a world in that greasy oily body of his. When he eats a hard-boiled egg that dropped on the floor, he accidentally eats a lethal Tony Montana-esque germ by the name of Thrax (Laurence Fishburne  The Matrix). Now, a white blood cell named Osmosis Jones (Chris Rock  SNL, Head of State) and a cold pill named Drix (David-Hyde Pierce  Frasier) must stop the germ from killing Frank. But can they catch him in time?
    This is a good flick. First off we'll start with the animation. The animation is basically simple, with no dazzling or unique aspects but it holds off pretty good and provides alot of fun. We get educational techniques without it actually being educational. The way that the animators make these different body parts into clubs, streets, and police stations are very imaginative and genius. I may be jumping the gun a bit, but that's how I feel. I think they used the same technique in this as they used for "The Iron Giant" where they place a computer character in with regular animation. Drix is computerized, while the other characters aren't. Nice job. I loved the colors and scenes, and they're all played off very well. 
    The actors seem to hold their ground in this one, but all of them are outshun by Chris Rock and his character which is basically the life of this flick. Without him, this is just another animated flick. He seems to make all the other characters seem like lightweights. David- Hyde Pierce uses his ineptitude well with his character Drix and is hilarious. William Shatner was also a great character as the spineless mayor of Frank's body who only seemed to care about re-election and not health. Look for a voice cameo by a famous child star/ Hollywood director as his rival who is striving for good health (I won't tell you). Laurence Fishburne is great as the evil Thrax who is very destructive. I thought he was cool. He was a mix of 70's blaxploitation villains with Tony Montana and Tony Soprano. He was very intimidating. Bill Murray is hilarious as the disgusting slob constantly being badgered by his daughter to become more healthier. The story plays off as a classroom educational body flick. This could be shown to a fifth grade class and they would leave knowing alot of the bodily functions. The story is great and very original.

The problem with this film is that the sub-plot with Bill Murray is outshun by the main plot with the body. I cared more about The animated characters than the actual characters. It seemed the directors seemed more focused on creating a story for the body.
I felt there could have been alot more to Bill Murray's character and alot more interaction with his daughter. Another problem was when we did see the plots with Murray, they were really gross. Eck. I was nauseous most of the time he was onscreen. The plot that almost made me hurl was when his zit popped in the teachers face. Eck.

I enjoyed it. It's a fun, dumb and gross comedy that kids will love.